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Park Seong-hoe
Seong Hoe Park(born October 3, 1947) is a Korean immunologist and pathologist and a distinguished professor of pathology at the Seoul National University College of Medicine. He served as the chair of the Department of Pathology(2000–2004), the chair of the Graduate Program of Immunology(2002–2006), the President of Center for Animal Resource Development(2004–2006) in Seoul National University. He was the president of the Korean Association of Immunologists(2000–2001). Throughout his career as a T cell immunologist, Park established the theory of T cell-T cell interaction in human thymus, in which T cells expressing MHC class II drive previously unrecognized types of T cells and provide another significant developmental mechanism of T cells. His another important achievement is the induction of antigen-specific T cell tolerance, which has been a distant dream of immunologists for pinpoint-targeted control of the immune system. He successfully inhibited porcine pancreatic islet graft rejection in primates by preconditioning the host for the development of tolerogenic dendritic cells before the xenotransplantation(J Exp Med. 208:2477-2488, 2011). In this experiment, Park suggested a theoretical base of the prevention of graft rejection and the treatment of autoimmune diseases without serious complication. Besides, he found the novel antigen JL1 on thymocytes, which has been developed as a therapeutic target for leukemia. Now he is the director of Transplantation Research Institute in Seoul National University College of Medicine, and his team is conducting the basic research on the induction of T cell tolerance and the application of it to various immune diseases.〔Park SH, Bae YM, Kim TJ, Ha IS, Kim S, Chi JG, Lee SK. HLA-DR expression in human fetal thymocytes. Hum Immunol. 33:294-298, 1992〕〔Park SH, Bae YM, Kwon HJ, Kim TJ, Kim J, Lee SJ, Lee SK. JL1, a novel differentiation antigen of human cortical thymocyte. J Exp Med. 178:1447-51, 1993
〕〔Choi EY, Park WS, Jung KC, Chung DH, Bae YM, Kim TJ, Song HG, Kim SH, Ham DI, Hahn JH, Kim J, Kim K, Hwang TS, ParkSH. Thymocytes positively select thymocytes in human system. Hum Immunol. 54:15-20,1997
〕〔Choi EY, Park WS, Jung KC, Kim SH, Kim YY, Lee WJ, ParkSH. Engagement of CD99 induces up-regulation of TCR and MHC class I and II molecules on the surface of human thymocytes. J Immunol, 161:749-754, 1998〕〔Kim SH, Choi EY, Shin YK, Kim TJ, Chung DH, Chang SI, Kim NK, ParkSH. Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (Mic2). Blood, 92:4287-4295, 1998〕〔Sohn HW, Choi EY, Kim SH, Lee I-S, Chung DH, Sung UA, Hwang DH, Cho SS, Jun BH, Jang JJ, Chi JG, ParkSH. Engagement of CD99 Induces Apoptosis Through a Calcineurin-Independent Pathway in Ewing's Sarcoma Cells. Am J Pathol, 153:1937-1945, 1998〕〔Kim SH, Shin YK, Lee IS, Bae YB, Sohn HW, Suh YH, Ree HJ, Rowe M, ParkSH. Viral latent membrane protein 1(LMP-1)-induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype. Blood, 95:294-300, 2000〕〔Shin YK, Choi EY, Kim SH, Chung J, Chung DH, Park WS, Jung KC, Kim HS, Park S, Kim HJ, Park MH, Min CK, Kim CC, ParkSH. Expression of Leukemia-Associated Antigen, JL1, in bone marrow and thymus. Am J Pathol, 158:1473-1480, 2001〕〔Sohn HW, Shin YK, Lee I-S, Bae YM, Suh YH, Kim MK, Kim TJ, Jung KC, Park WS, Park C-S, Chung DH, Ahn K, Kim IS, Ko YH, Bang YJ, Kim CW and ParkSH. CD99 regulates the transport of MHC class I molecules from the Golgi complex to the cell surface. J Immunol, 166:787-794, 2001〕〔Lee IS, Shin YK, Chung DH, ParkSH. LMP1-induced downregulation of CD99 molecules in Hodgkin and Reed-Sternberg cells. Leuk Lymphoma, 42:587-94, 2001〕〔Lee I-S, Kim MK, Choi EY, Anja Mehl, Jung KC, Gil MC, Rowe M, ParkSH.CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-κB. Blood, 97:3596-3604, 2001〕〔Park SH, Shin YK, Suh YH, Park WS, Ban YL, Choi H-S, Park HJ, Jung KC. Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region. Gene, 353:177-88, 2005〕〔Choi EY, Jung KC, Park HJ, Chung DH, Song JS, Yang SD, Simpson E, ParkSH. Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells. Immunity. 23:387-96, 2005〕〔Lee YJ, Jung KC, ParkSH. MHC class II-dependent T-T interactions create a diverse, functional and immunoregulatory reaction circle. Immunol Cell Biol. 87:65-71, 2009〕〔Lee YJ, J YK, Kang BH, Chung DH, Park C-G, Shin HY, Jung KC, ParkSH. Generation of PLZF+ CD4+ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans. J Exp Med. 207:237-246, 2010〕〔Min HS, Lee YJ, Jeon YK, Kim EJ, Kang BH, Jung KC, Chang CH, ParkSH. MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells. J Immunol. 186:5749-57, 2011〕〔Jung KC, Park CG, Jeon YK, Park HJ, Ban YL, Min HS, Kim EJ, Kim JH, Kang BH, Park SP, Bae Y, Yoon IH, Kim YH, Lee JI, Kim JS, Shin JS, Yang J, Kim SJ, Rostlund E, Muller WA, ParkSH. In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates. J Exp Med. 208:2477-2488, 2011〕
==Education==
Seong Hoe Park was born in 1947 and spent his childhood in Incheon and moved to Seoul attending Seoul High School through the age of 18. He graduated from Seoul National University College of Medicine in 1975 and received his PhD. in Pathology from the same college in 1983. After the doctor’s degree, he worked as a research Fellow in the Harvard university Dana-Farber Cancer Institute.
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